SU11274

SU11274 (PKI-SU11274) is a Met kinase inhibitor with IC50 of 10 nM. c-Met is a prognostic marker and potential therapeutic target in clear cell renal cell carcinoma. c-Met protein was activated in all cell lines, and SU11274 can block proliferation (and colony formation). c-Met inhibition could significantly suppress cell survival and proliferation as well as enhance the radiosensitivity of DU145 cells. SU11274 on DU145 cells may include the inhibition of c-Met signaling, depolarization of the mitochondrial membrane potential, impairment of DNA repair function, abrogation of cell cycle arrest, and enhancement of cell death.