Stemolecule LDN-193189

LDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC₅₀ = 5nM and 30nM respectively)¹. LDN-193189 was derived from structure-activity relationship studies of dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation^1-3. LDN-193189 only weakly inhibits ALK4, ALK5, and ALK7¹. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms^4,5. LDN-193189has been used to reduce ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva¹. Stemolecule LDN-193189 is a hydrochloride salt.