Antibodies
Sodium 4-Aminosalicylate
- 貨號 Cat. No.
- S4073
- 規格 Size
- 10mM/1mLã€50mg
- 品牌 Brand
- Selleckchem
Description
Sodium 4-Aminosalicylate
Catalog No.S4073
Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.
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Biological Activity
| Description | Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging. | |||||
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| In vitro | 5-Aminosalicylate reacts promptly with DPPH, suggesting a potent radical scavenger activity. 5-Aminosalicylate exhibits peroxyl radical scavenging activity generated by the water-soluble 2,2’-azobis-(2-amidinopropane hydrochloride) azoinitiator of peroxyl radicals, as evidenced by the inhibition of cis-parinaric acid fluorescence decay or oxygen consumption. 5-Aminosalicylate rapidly scavenges peroxyl radicals in the aqueous phase, producing a concentration-dependent inhibition period similar to Trolox or cysteine, suggesting an antioxidant activity of chain-breaking type. [1] [14C]5-Aminosalicylate transforms to a number of metabolites, among which we have characterized salicylate and gentisate, in activated mononuclear cells and activated granulocytes. 5-Aminosalicylate (0.65 mM) diminishes the lethal effect on cultured Chinese hamster ovary cells of adding either superoxide radical or hydrogen peroxide. [2] Aminosalicylate (25 mM) stimulates phospholipase D in a time- and concentration-dependent manner via a pathway involving inositol 1,4,5-trisphosphate generation, calcium fluxes, and Gi/Go in cultured mouse peritoneal macrophages. 5-aminosalicylate (20 mM) increases the levels of inositol 1,4,5-trisphosphate by 260% after treatment of macrophages. 5-aminosalicylate (5 mM) potentiates the activation of PLD by protein kinase C in cultured mouse peritoneal macrophages. [3] 5-aminosalicylate (0.1 mM) decreases the LTB4 synthesis in a dose-related fashion in isolated colonic mucosal cells, thus diminishes the LTB4/PGE2 ratio. [4] 5-aminosalicylate (0.1 mg/mL) is preferentially transported in the basolateral (BL) to apical (AP) direction, and the N-acetyl metabolite appeared only in the AP compartment. [5] | |||||
| In vivo | 5-aminosalicylate (7.5 mg/mL, regional perfusions) results in the appearance of N-acetyl-5-aminosalicylic acid in the intestinal lumen in the anesthetized rat. [5] | |||||
| Features | 5-Aminosalicylate is considered to be the active moiety of sulfasalazine. | |||||
Protocol(Only for Reference)
References
Chemical Information
Download Sodium 4-Aminosalicylate SDF
| Molecular Weight (MW) | 211.15 |
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| Formula | C7H7NO3.2H2O.Na |
| CAS No. | 6018-19-5 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | PAS Sodium |
| Solubility (25°C) * | In vitro | DMSO | 42 mg/mL (198 mM) |
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| Water | 42 mg/mL (198 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | Benzoic acid, 4-amino-2-hydroxy-, sodium salt, hydrate (1:1:2) |
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Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
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| Mass(mg) | 0.21115 | 2.1115 | 4.223 | 6.3345 |
