SMMHC Antibody

Smooth muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC), and 2 regulatory light chain subunits (MLC-2). Smooth muscle myosin heavy chain (myosin-11 or SMMHC), a cytoplasmic structural protein, is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early in smooth muscle development and specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1 and MHC-2. Defects in SMMHC are the cause of aortic aneurysm familial thoracic type 4 and a chromosomal aberration involving SMMHC is found in acute myeloid leukemia.