SMMHC Antibody

h1 class=titleSMMHC Antibody/h1
div id=node-1666 class=node ntype-antibodiesRabbit Polyclonal
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h4Catalog Number/h4
pstrong250861/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
h4Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pCardiac myosin heavy chain (myosin-11 or SMMHC) is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC), and 2 regulatory light chain subunits (MLC-2). SMMHC, a cytoplasmic structural protein, is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early in smooth muscle development and specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1 and MHC-2. Defects in SMMHC are the cause of aortic aneurysm familial thoracic type 4 and a chromosomal aberration involving SMMHC is found in acute myeloid leukemia./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pMyosin-11; Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; SMMHC; MYH11/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P35749P35749/abr /
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h4Clonality/h4
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h4Antigen/h4
pnbsp;/p
pKLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SMMHC./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H | M | R/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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