SMAD6 (5H3) Antibody

SMAD6 (Mothers against decapentaplegic homolog 6) protein is an antagonist of signaling by TGF-beta type 1 receptor superfamily members. It has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. SMAD6 is ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.