Sheep antibody to alpha synuclein (116-131): Affinity purified
Antibodies
- 貨號 Cat. No.
- S-075-50
- 規格 Size
- 50 µg
- 品牌 Brand
- Biosensis
- Application 應用
- ELISA 、 IF, Frozen 、 IF(P), Paraffin embedded 、 IH(P), Paraffin embedded 、 IHC, Frozen 、 WB
- Reactivity
- Human 、 Mouse 、 other rodents 、 Rat
- Host
- Sheep
- Clonality
- Polyclonal
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
Antibody_Isotype
(Antibody only) :
Application_Details :
IHC, WB, ELISA. Recommended to be used at a concentration of 1µg/mL for immunohistochemistry (Paraffin sections); 0.5 µg/mL for WB and immunoblot. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Background_Info :
Clone_Name
(AB only, monoclonals) :
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=51
Description (Long Description) :
Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.
Expiry_Date :
12 months after purchase
Format (Form) :
Lyophilized
Immunogen (Antigen) :A synthetic peptide (CMPVDPDNEAYEMPSEE) of human alpha synuclein protein (aa: 116-131) conjugated to diphtheria toxoid has been used as the immunogen.
Kit_Components :
MSDS (File name) :
