SDMA (Symmetric Dimethylarginine) ELISA

The dosage of most drugs must be adapted in renal insufficiency, making
accurate assessment of renal function a prerequisite in clinical medicine.
Furthermore, even a modest decline in renal function has been recognized as a
cardiovascular risk.
In clinical practice serum creatinine is typically used to asses renal function, but
this serum creatinine does not increase at modest decline in renal function.
Consequently, there is an ongoing search for suitable endogenous markers of
renal function.
SDMA is a methylated derivative of L-arginine which is strictly eliminated by
renal extraction, thus the SDMA plasma level is strongly correlated to renal
function. In 18 studies with more than 2136 patients systemic SDMA
concentrations correlated highly with inuline clearance, as well as with various
clearance estimates combined and serum creatinine. With respect to this, SDMA
exhibits properties of a reliable marker of renal dysfunction.
Moreover, there are hints that increased SDMA correlates with total sequential
organ failure, indicating both renal and hepatic failure, and with an increased
cardiovascular risk.