SCD1 Inhibitor
- 貨號 Cat. No.
- 1716-1
- 規格 Size
- 1 mg
Description
Alternate Name/Synonyms: 4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₀H₂₂ClN₃O₃
Molecular Weight: 387.86
Purity: ≥95% by HPLC
Solubility: DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Description: Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: ICâ‚…â‚€ = 37 nM for hSCD1, <4 nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterations in macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists.
Handling: Protect from air and light