SB590885

SB-590885 is another selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.It has been used to overcome the dependence of MAPK signaling and tumor cell growth on BRaf kinase activity.In melanoma and colorectal cancer cell lines with B-Raf V600E mutation, an effective inhibition of cell proliferation was achieved at
concentrations that blocked ERK phosphorylation.The inhibition of MAP kinase is one of the vital ways to get rid of un-wanted tumor growth. SB590885 also act as an angiogenesis inhibitor and also helps in the research studies of different important kinase pathways.