SB-431542

Alternate Name/Synonyms: 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 301836-41-9

Molecular Formula: C₂₂H₁₈N₄O₃

Molecular Weight: 384.39

Purity: ≥98%

Solubility: DMSO (20 mg/ml) or EtOH (2 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: A potent and selective inhibitor of the TGF-β1 receptor ALK5 (ICâ‚…â‚€ = 94 nM). It inhibits ALK4 only at higher concentrations (ICâ‚…â‚€ = 140 nM). Suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes their differentiation through its effect on Smad signaling pathway.

Handling: Protect from air and light