SB 203580

貨號 Cat. No.
A10824-25
規格 Size
25mg
品牌 Brand
AdooQ

Description

Chemical Information















































Catalog Num A10824
Actions Inhibitor
M. Wt 377.4
Formula C21H16FN3OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 152121-47-6
Synonyms SB-203580, SB203580
SMILES code CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
Chemical Name 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine



Biological Activity















Description
SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.

Targets












p38 MAPK (THP-1 cells) PKB (THP-1 cells)
0.3 μM-0.5 μM 3 μM-5 μM






Solubility






















Solubility (25°C)* In vitro DMSO 43 mg/mL (113.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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