RTN3 (10A8) Antibody

RTN3 (Reticulon 3) is a multi-pass membrane protein. The reticulons are a group of highly conserved proteins with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. RTN3 inhibits BACE1 activity and amyloid precursor protein processing, also may induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis.