- 貨號 Cat. No.
- RTT-400
- 規格 Size
- 5 μg 5x5 μg 10μg 10μgx10μg 0.1mg
Description
rTamapin
A Novel Blocker of KCa2 (SK, small conductance Ca 2+-activated K+) Channels
Sizes: |
5 mg |
5 x 5 mg |
10 mg |
5 x 10 mg |
0.1 mg |
|
Sequence: |
AFCNLRRCELSCRSLGLLGKCIGEECKCVPY
|
Bioassay: |
Activation of rTamapin sensitive outward current by intracellular Ca2+ injection into Xenopus oocytes
expressing SK2 (KCa2.2) channels. The arrow and vertical bar represents time of intracellular injection
and period of toxin perfusion, respectively.
|
 |
Model structure of Tamapin, based on its homology to scyllatoxin (1SCY).
This class of peptides possesses the alpha-KTX-5 family scaffold, which
serves as "poreplungers".
|
1.
|
Rodriguez de la Vega, R.C. and Possani, L.D. (2004) Toxicon 43, 865. |
2.
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Pedarzani, P. et al. (2002) J. Biol. Chem. 277, 46101. |
Tamapin is a 31 amino acid peptidyl toxin, isolated from the venom of the Indian red scorpion, Mesobuthus tamulus, and is classified as a-5.4 scorpion toxin family (P59869).1 Native Tamapin blocks KCa2 channels in pyramidal neurons of the hippocampus as well as in cell lines expressing distinct KCa2 channel subunits. Tamapin displays a remarkable selectivity for KCa2.2 (SK2/KCNN2, IC50=24pM) versus KCa2.1 (SK1/KCNN1, approx 1750 fold) channels.2 500 nM of rTamapin (#RTT-400) completely blocked KCa2.2 mediated currents in Xenopus oocytes.
We are pleased to make available this novel toxin available to the research community.
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