- 貨號 Cat. No.
- R-400
- 規格 Size
- 0.5 mg 5x0.5 mg 1mg
Description
Resiniferatoxin
A Potent and Selective Agonist of the TRPV1
Sizes: |
0.5 mg |
5 x 0.5 mg |
1 mg |
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Bioassay: |
Resiniferatoxin induced Ca2+ influx via activation of vanilloid receptor 1 (VR1, TRPV1). |
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VR1 stably expressed HEK 293 cells were loaded with 1mM flou-3 AM and then stimulated with Resiniferatoxin (#R-400). The left panel shows the intracellular Ca2+ levels 10 sec post stimulation with different concentrations of Resiniferatoxin plotted against drug concentration (ED50 2 mM) . The right panel shows cytoplasmic Ca2+ before and after stimulation of cells with 10 mM Resiniferatoxin. |
1.
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Szallasi, A. and Blumberg, P.M. (1989) Neurosci. 30, 515. |
2.
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Raisinghani, M. et al. (2005) J. Physiol. 567, 771. |
Resiniferatoxin is a potent and selective agonist of the TRPV1 (Vanilloid/Capsaicin receptor) channel.1 Application of sub-nanomolar concentrations of Resiniferatoxin irreversibly induces a sustained slow current and depolarization in DRG neurons.2
Treatment of rats with Resiniferatoxin, like treatment with capsaicin, causes hypothermia, neurogenic inflammation and pain. These responses were followed by a loss of thermoregulation, by desensiization to neurogenic inflammation and by chemical and thermal analgesia, with a cross-tolerance between Resiniferatoxin and capsaicin.1
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