RANTES Polyclonal Antibody
- 貨號 Cat. No.
- 5321-100
- 規格 Size
- 100 ug
Description
IMMUNOGEN: E. coli-expressed human RANTES
HOST: Rabbit
FORMULATION: 100 ug (0.5 mg/ml) purified rabbit anti-human RANTES polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
SPECIES REACTIVITY: human
STORAGE CONDITIONS: Store at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles.
BACKGROUND DESCRIPTION: RANTES (regulated upon activation, normal T-cell expressed and secreted) is a 70-amino acid CC chemokine originally cloned from T-cell-specific sequences-enriched cDNA libraries. Both human and murine RANTES are chemotactic for monocytes. Human RANTES is also a chemoattractant for T-cells and eosinophils, as well as an activator of basophils for histamine release. In contrast to other CC chemokines, RANTES is only slowly expressed after activation of leukocytes. It is involved in a number of pathological conditions like chronic inflammation and autoimmune diseases.
APPLICATION AND SPECIFICITY The antibody can be used for Western blot analysis (0.5-1 ug/ml) and neutralization (2-10 ug/ml). However, the optimal conditions should be determined individually.
FOR RESEARCH USE ONLY. Not to be used in humans.