- 貨號 Cat. No.
- RTA-390
- 規格 Size
- 5 μg 5x5 μg 10μg 5x10μg 0.1mg
Description
rAgitoxin-3
A Potent Blocker of Kv1.3 K+ Channels
Sizes: |
5 mg |
5 x 5 mg |
10 mg |
5 x 10 mg |
0.1 mg |
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Sequence: |
GVPIN VPCTG SPQCI KPCKD AGMRF GKCMN RKCHC TPK |
Bioassay: |
This lot was tested to confirm its ability to inhibit potently (20nM) Kv1.3 K+ channels expressed in Xenopus oocytes. |
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Left: Time course of Kv1.3 current amplitude in response to test pulse of 100 ms to 0 mV (holding potential -100 mV). 20 nM rAgitoxin-3 were perfused at the period marked by the horizontal bar.
Right: Traces of Kv1.3 currents before (red) and during application of the toxin.
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1.
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Garcia, M.L. et al. (1994) Biochemistry 33, 6834.
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Native Agitoxin-3 was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus.1 Like Agitoxin-2 (#RTA-420), it is a potent blocker of the Shaker voltage-gated K+ channels as well as the mammalian homologues of Shaker.1
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