- 貨號 Cat. No.
- RTA-420
- 規格 Size
- 5 μg 5x5 μg 10μg 5x10μg 0.1mg
Description
rAgitoxin-2
A Potent Blocker of Kv1.3 K+ Channels
Sizes: |
5 mg |
5 x 5 mg |
10 mg |
5 x 10 mg |
0.1 mg |
|
Sequence: |
GVPIN VSCTG SPQCI KPCKD AGMRF GKCMN RKCHC TPK |
Bioassay: |
rAgitoxin-2 was tested to confirm its ability to inhibit potently Kv1.3 K+ channels expressed in Xenopus oocytes.
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Left: Time course of Kv1.3 current amplitude in response to test pulse of 100 ms to 0 mV (holding potential -100 mV). increasing concentrations of rAgitoxin-2 were perfused at the period marked by the horizontal bars with the concentration marked in nM.
Right: Traces of Kv1.3 currents before and during application of the toxin at increasing concentrations (indicated in the index).
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1.
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Garcia, M.L. et al. (1994) Biochemistry 33, 6834. |
2.
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Cayabyab, F.S. et al. (2000) Eur. J. Neurosci. 12, 1949. |
Native Agitoxin-2 was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus.1 Agitoxin-2 inhibited the native Kv1.3-like current in cultured microglia by 72% at 5 nM and Kv1.3 in MLS-9 cells by 87%.2 rAgitoxin-2 is a potent blocker of the Shaker voltage-gated K+-channels as well as the mammalian homologues of Shaker.1
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