rAgitoxin-1
- 貨號 Cat. No.
- RTA-150
- 規格 Size
- 5 μg 5x5 μg 10μg 5x10μg 0.1mg
Description
rAgitoxin-1
A Potent Blocker of Kv1.3 K+ Channels
| Product#: | RTA-150 |
| Sizes: |
| 5 mg |
| 5 x 5 mg |
| 10 mg |
| 5 x 10 mg |
| 0.1 mg |
| M.W.: | 4015 |
| Sequence: | GVPINVKCTG SPQCLKPCKD AGMRFGKCIN GKCHCTPK |
| Purity: | >98% |
| Bioassay: |
| rAgitoxin-1 was tested to confirm its ability to inhibit potently (<1nM) Kv1.3 K+ channels expressed in Xenopus oocytes.1 |
 |
Left: Example current responses to 100 ms depolarization to 0 mV from holding potential of ?00 mV, delivered every 10 seconds before (red) and during application of 10 nM rAgitoxin-1. Right: Time course of amplitude inhibition. The effects of 10 and 50 nM rAgitoxin-1 on Kv1.3 current amplitude are shown. The horizontal bars indicate the periods of toxin perfusion. |
| References: |
1. | Garcia, M.L. et al. (1994) Biochemistry 33, 6834. |
Agitoxin 1 was originally isolated from L. quinquestriatus hebraeus. rAgitoxin-1 is a recombinant peptide expressed in and extracted from E. coli and purified to homogeneity. Like Agitoxin-2 (#RTA-420), rAgitoxin-1 is a potent blocker of the Shaker voltage-gated K+ channels as well as the mammalian homologues of Shaker.1