RAD17 Antibody

Cell cycle checkpoint protein RAD17 (RAD17) is essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. RAD17 has a weak ATPase activity required for binding to chromatin. RAD17 participates in the recruitment of the RAD1-RAD9-HUS1 complex onto chromatin, and in CHEK1 activation. RAD17 is a sensor of DNA replication progression, and is involved in homologous recombination.