Rabbit polyclonal antibody to Hypoxia-inducible factor-2 alpha (282-301): Affinity purified

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Endothelial PAS domain-containing protein 1; EPAS-1; Hypoxia-inducible factor 2 alpha; HIF-2 alpha; HIF2 alpha; Epas1; Hif2a;

 

Antibody_Isotype
(Antibody only) :

 

Application_Details :

Western Blotting (WB). A concentration of 0.1-0.5 µg/mL is recommended for WB. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) :

 

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=1603

 

Description (Long Description) : 

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (Reference: uniprot.org).

 

Expiry_Date : 

12 months after purchase if stored lyophilised.

 

Format (Form) : 

Lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05mg Thimerosal, 0.05 mg NaN3.

 

Immunogen (Antigen) :A synthetic peptide (HALDSENMTKSHQNLCTKG) corresponding to a peptide sequence in the middle region (282-301) from human Hypoxia-inducible factor-2 alpha. This sequence is identical to rat and mouse HIF2A.

 

Kit_Components :

 

MSDS (File name) :