Rabbit polyclonal antibody to human Notch 1 (1601-1619): Affinity purified

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1; NOTCH1; TAN1;

 

Antibody_Isotype
(Antibody only) :

 

Application_Details :

Western Blotting (WB). A concentration of 1.0 µg/mL is recommended for WB. Human Notch 1 (precursor) has a predicted length of 2,555 residues and MW of 273 kDa. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) :

 

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=599

 

Description (Long Description) : 

Notch 1 is initially synthesized as inactive precursor molecule. During maturation, the molecule is cleaved at its extracellular domain. Upon binding to a ligand such as Delta1, a C-terminal Notch 1 fragment is released and further cleaved. The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription. Notch 1 is mostly found in fetal spleen, brain stem and lung tissues and adult lymphoid tissues.

 

Expiry_Date : 

12 months after purchase

 

Format (Form) : 

Lyophilized with 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3

 

Immunogen (Antigen) :A synthetic peptide (HTNVVFKRDAHGQQMIFPY) corresponding to a region (1601-1619) from human Notch 1 (precursor). To enhance the immunological response, this peptide was coupled to carrier protein BSA.

 

Kit_Components :

 

MSDS (File name) :