Rabbit polyclonal antibody to human nicotinic acetylcholine receptor subunit alpha-1 (22-36): Affinity purified

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Acetylcholine receptor subunit alpha; CHRNA1; ACHRA; CHNRA;

 

Antibody_Isotype
(Antibody only) :

 

Application_Details :

Western Blotting (WB). A concentration of 0.1-0.5 µg/mL is recommended for WB. Human acetylcholine receptor subunit alpha-1 (isoform 2) has a predicted length of 482 amino acids and MW of 55 kDa. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) :

 

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=619

 

Description (Long Description) : 

Upon binding of acetylcholine, the acetylcholine receptor responds by undergoing an extensive change of conformation which affects its alpha and beta subunits and leads to the opening of an ion-conducting channel across the plasma membrane. At least 2 isoforms of the alpha-1 subunit are produced from alternate splicing. Isoform 1 is only expressed in skeletal muscle whereas isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.

 

Expiry_Date : 

12 months after purchase

 

Format (Form) : 

Lyophilized with 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3

 

Immunogen (Antigen) :A synthetic peptide (EHETRLVAKLFKDYS) corresponding to a region (22-36) from the N-terminus of human nicotinic acetylcholine receptor subunit alpha-1.

 

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MSDS (File name) :