Rabbit polyclonal antibody to human Metalloproteinase inhibitor 2 (205-220): Affinity purified

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Tissue inhibitor of metalloproteinases 2; TIMP-2; CSC-21K; TIMP2;

 

Antibody_Isotype
(Antibody only) :

 

Application_Details :

Western Blotting (WB). A concentration of 1.0-2.0 µg/mL is recommended for WB. Human TIMP2 (precursor) has a predicted length of 220 residues and MW of 24 kDa. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) :

 

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=578

 

Description (Long Description) : 

The matrix metalloproteinases (MMPs) are a large family of  zinc endopeptidases that  degrade extracellular matrix components such as fibronectin and collagen type III. The tissue inhibitors of metalloproteinase (TIMPs) complex with these matrix metalloproteinases and irreversibly inactivate them. The TIMP proteins are  homologous and are either secreted in soluble form (TIMP1, TIMP2 and TIMP4) or bind to extracellular matrix components (TIMP3). Metalloproteinase inhibitor 2 (TIMP2) is known to inhibit MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

 

Expiry_Date : 

12 months after purchase

 

Format (Form) : 

Liquid (0.5mL). 50% glycerol, 0.9mg NaCl and 0.2mg Na2HPO4

 

Immunogen (Antigen) :A synthetic peptide (RGAAPPKQEFLDIEDP) corresponding to a region (205-220) from the C-terminus of human Metalloproteinase inhibitor 2. To enhance the immunological response, this peptide was coupled to carrier protein BSA.

 

Kit_Components :

 

MSDS (File name) :