Rabbit polyclonal antibody to human Integrin alpha-6 (CD49f): Affinity purified

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD_antigen: CD49f

 

Antibody_Isotype
(Antibody only) :

 

Application_Details :

Western blotting (0.1-0.5 ug/mL) and direct ELISA (0.1-0.5 ug/mL). Other applications have not been tested. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) :

 

Datasheet_Link : https://www.biosensis.com/pdf_datasheet.php?products_id=1834

 

Description (Long Description) : 

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). Source: uniprot.org. In new work published by L.Barbar [PPR83158] the authors demonstrate that CD49f is an effective marker effective marker for sorting functional human astrocytes from mixed cultures.

 

Expiry_Date : 

12 months after purchase if unopened.

 

Format (Form) : 

Lyophilized

 

Immunogen (Antigen) :E.coli-derived human Integrin alpha 6/ITGA6 (CD49f) recombinant protein (amino acids Q189-K917).

 

Kit_Components :

 

MSDS (File name) :