Rabbit polyclonal antibody to human DNA topoisomerase 2-alpha (1466-1480): Affinity purified

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

EC 5.99.1.3; DNA topoisomerase II; alpha isozyme; TOP2A; TOP2;

 

Antibody_Isotype
(Antibody only) :

 

Application_Details :

Western Blotting (WB). A concentration of 1.0-2.0 µg/mL is recommended for WB. Human TOP2A (isoform 1) has a predicted length of 1,531 residues and MW of 174 kDa. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

 

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Clone_Name
(AB only, monoclonals) :

 

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=580

 

Description (Long Description) : 

DNA topoisomerase 2 catalyzes the transient breaking and rejoining of double stranded DNA during events such as DNA synthesis and transcription. Two forms of this enzyme exist, alpha and beta. DNA topoisomerase 2 alpha (TOP2A) is localized to chromosome 17 and the beta gene is localized to chromosome 3. At least 4 isoforms of TOP2A are produced by alternate splicing.

 

Expiry_Date : 

12 months after purchase

 

Format (Form) : 

Lyophilized with 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3

 

Immunogen (Antigen) :A synthetic peptide (RKPSTSDDSDSNFEK) corresponding to a region (1466-1480) from human DNA topoisomerase 2-alpha. To enhance the immunological response, this peptide was coupled to carrier protein BSA.

 

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MSDS (File name) :