Rabbit antibody to the Tyrosine Kinase Receptor C (TrkC): whole serum

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Tropomyosin-related kinase receptor; NT-3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C; NTRK3; TRKC

 

Antibody_Isotype
(Antibody only) : Mixed

 

Application_Details :

IHC. A dilution of 1:1000 to 1:3000 is recommended for this application. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) :

 

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=223

 

Description (Long Description) : 

TrkC is a member of the neurotrophic tyrosine receptor kinase family. TrkC is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC is the receptor for neurotrophin-3 (NT-3).  Signalling through TrkC leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. ALTERNATIVE PRODUCTS: 4 named isoforms produced by alternative splicing. Additional isoforms seem to exist. Mutations in TrkC have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

 

Expiry_Date : 

 

Format (Form) : 

Lyophilized

 

Immunogen (Antigen) :Extracellular domain of glycosylated human TrkC protein produced in CHO cells was used as the immunogen.

 

Kit_Components :

 

MSDS (File name) :