QX-314 (Br- salt)
- 貨號 Cat. No.
- Q-100
- 規格 Size
- 500 mg 1g 2.5g
Description
QX-314 (Br- salt)
A Local Anesthetic Blocker of some NaV channels.
| Product#: | Q-100 |
| Sizes: |
| 500 mg |
| 1 g |
| 2.5 g |
This local anesthetic is a blocker of voltage-dependent Na+ channels. QX-314 blocks all Nav channels once exposed to the intracellular face of the channel protein. However, this compound can penetrate the cell interior once applied extracellulary, via certain types of Nav channels, it can permeate and exert blocking activity via TTX sensitive channels.1 Intracellular recording from inferior olivary neurons in brain stem slice preparation demonstrated that Na+ - dependent action potential was completely blocked for approximately five minutes after impalement with a microelectrode containing 50mM QX-314, whereas the low-threshold Ca2+ spike was still generated.2 QX-314 is widely used to block Nav channels as well as a tool in neurophysiological recordings.2-5
| M.W.: | 343.3 |
 |
| Purity: | >99% |
| Bioassay: |
| Inhibition of native NaV currents in ND7-23 cells. |
 |
| Legend: Inhibition of native NaV currents in ND7-23 cells. Inward currents elicited from holding potential of -100 mV, by a 40 ms test pulse to -10 mV delivered every 15 seconds. Superimposed traces of control current (black) and during bath perfusion of 2.5 mM (blue) and 25 mM (orange) QX-314. |
| References: |
1. | Sunami, A. et al. (2000) P.N.A.S. USA 97, 2326. |
2. | Llinas, R. and Yarom, Y. (1981), J. Physiol. 315, 549. |
3. | Congar, P. et al. (1995) J. Neurophysiol. 73, 421. |
4. | Li, D.P. et al. (2005) J. Neurophysiol. 93, 393. |
5. | Koike-Tani, M. (2005) J. Neurosci. 25, 199. |