- 貨號 Cat. No.
- Q-200
- 規格 Size
- 25 mg 5x25mg
Description
QX-222
A Quarternary Derivative of the Local Anesthetic Lidocaine.
Bioassay: |
Inhibition of native NaV channels in ND7-23 cells by QX-222 external application. |
 |
Inhibitory effect of 10 mM QX-222 on native NaV currents in ND7-23 cells, using the whole cell patch clamp method. Inward currents were elicited from holding potential of -100 mV by a 40 ms test pulse to -10 mV delivered every 10 seconds. Superimposed traces show the response before (black) and during bath application of 10 mM QX-222 (orange). |
1.
|
Gintant G. A. and Hoffman B. F. (1984) Pflugers Arch. 400, 121. |
2.
|
Tsang, S. Y. et al. (2005) Mol. Pharmacol. 67, 424. |
3.
|
Neher E. and Steinbach J. H. (1978) J. Physiol. 277, 153. |
QX-222 is a quarternary derivative of the local anesthetic Lidocaine. It was shown to block NaV currents and channels in a use dependent manner.1 The mechanism of block involves intracellular binding site, but some NaV channels facilitate the passage of QX-222 via the open channel.2 In addition it was shown to inhibit nicotinic ACh receptor channels.3
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