Purvalanol B

Purvalanol B is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.Purvalanol B is Selective over a range of other protein kinases (IC50 > 10,000 nM).It Shown to have antiproliferative properties, mediated by p42/p44 MAPK. Purvalanol inhibited the nuclear accumulation of p42/p44 MAPK, an event dependent on the catalytic activity of these kinases .