PTP1B Antibody

Antibody Target :PTP1B

Host: Mouse

Antibody Type: Monoclonal

Isotype: Mouse IgG1

Antibody Form: Mouse ascites with 0.09% (W/V) sodium azide.

Immunogen Sequence: Recombinant protein encoding amino acids 1-321 of human PTP1B

Accession#: P18031

Gene ID: 5770

Appearance: Colorless liquid

Concentration: 0.25 mg/ml

Formulation: 100 µg (0.25 mg/ml) mouse monoclonal IgG1 antibody supplied in PBS with 0.09% (W/V) sodium azide.

Purification:

Species Reactivity: hu/ms

Application: ELISA/WB

Application & Usage: The antibody can be used for ELISA (0.25 µg/ml) and Western blotting (0.5 – 2.5 µg/ml).

Storage Temp.: -20 °C

Shipping : gel pack

Shelf Life: 12 months

Handling: The antibody solution should be gently mixed before use.

Brief Background Descriptions: PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.