PTP-1B Antibody

h1 class=titlePTP-1B Antibody/h1
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h4Catalog Number/h4
pstrong250841/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
h4Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pThe protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and indentified based in its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters soecifically in tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control and cell response to interferon stimulation. It belongs to the protein - tyrosine phosphatase family, non-receptor class 1 subfamily. [tissue specifity] Most abundant in testis but also found in kidne, spleen, muscle, liver, heart and brain. May play an important part in CKII and p60c-src-induced signal tranduction cascades./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
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h4Accession No./h4
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h4Clonality/h4
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h4Antigen/h4
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pKLH-conjugated synthetic peptide encompassing a sequence within the N/C-term region of human protein./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H | M | R/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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