PTK7 (4F9) Antibody

PTK7 (Protein-tyrosine kinase 7) is a member of the receptor protein tyrosine kinases. They transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. PTK7 is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. It is thought to be expressed in colon carcinomas but not in normal colon, therefore may be a marker for or may be involved in tumor progression. It is highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells, but not expressed in colon.