PTEN Peptide

h1 class=titlePTEN Peptide/h1
div class=node ntype-peptides id=node-1288
div class=contentstyle type=text/css
!--
h4 {
margin: 30px 0 0 0;
padding: 0;
border-top: 1px solid #bbb;
background: #f8f8f8;
}
.descriptionpad {
margin: 10px;
}
--/style
div class=product-table
table cellspacing=10 cellpadding=0 width=100% border=0
tbody
tr
td valign=top width=50%
h4Catalog Number/h4
pstrong350507/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
h4Price/h4
pstrong$50.00/strong/p
/td
td valign=top
pnbsp;/p
/td
/tr
/tbody
/table
div class=descriptionpad
h4Description/h4
pPTEN is a dual-specificity protein phosphatase, dephosphorylating tyrosine-, threonine- and serine-phosphorylated proteins. PTEN has also a lipid phosphatase activity that is critical for its tumor suppression function. PTEN antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. Defects in PTEN are the cause of numerous cancers such as in Cowden disease (breast, thyroid and skin cancer predisposition), Lhermitte-Duclos disease, and head and neck squamous cell carcinoma./p
/div
table cellspacing=10 cellpadding=0 width=100% border=0
tbody
tr
td valign=top width=50%
h4Format/h4
pnbsp;/p
pEach vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect./p
pnbsp;/p
h4Data and Images/h4
/td
td valign=top
h4Product Citations/h4
pnbsp;/p
h4Recommended Products/h4
pa href=http://abbiotec.com/antibodies/pten-antibody200145 PTEN Antibody/abr /
nbsp;/p
h4Alternate Names/h4
pPhosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Phosphatase and tensin homolog; Mutated in multiple advanced cancers 1; MMAC1, TEP1/p
h4Accession No./h4
pa class=accession-link href=http://www.expasy.org/uniprot/P60484 target=_blankP60484/abr /
a class=accession-link href=http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=proteinamp;id=73765544 target=_blankNP_000305/abr /
nbsp;/p
h4MW/h4
p2243.4 g/mol/p
h4Sequence/h4
pThe synthetic peptide used to raise the antibody Cat. No. 200145 is selected from a sequence within the N-term region of human PTEN. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended./p
h4Composition/h4
pnbsp;/p
pC94H151N31O31S1/p
pnbsp;/p
h4Purity/h4
pPurity gt; 80% by HPLC/p
h4Solubility/h4
pDistilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile./p
h4Storage/h4
pStore at -20deg;C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20deg;C./p
/td
/tr
/tbody
/table
/div
/div
/div