Prucalopride

Prucalopride (brand name Resolor) is a selective, high affinity 5-HT4 receptor agonist with Ki of 2.5 nM and 8 nM for 5-HT4A and 5-HT4B receptor, respectively. Prucalopride has >150-fold higher affinity for 5-HT4 receptors than for other receptors. Prucalopride induces contractions in a concentration-dependent manner with pEC50 of 7.5. Prucalopride (4 mg) significantly reduced the need for straining versus placebo (p < 0.05). In vitro data indicate that prucalopride has a low interaction potential, and therapeutic concentrations of prucalopride are not expected to affect the CYP-mediated metabolism of co-medicated medicinal products. Prucalopride significantly improved bowel function and reduced the severity of symptoms in patients with severe chronic constipation over 12 weeks.