Proteasome Inhibitor (MG-132, Z-LLL-CHO)

Alternate Name/Synonyms: Z-Leu-Leu-Leu-CHO; Z-LLL-CHO

Peptide sequence: Z-Leu-Leu-Leu-CHO; Z-LLL-CHO

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 133407-82-6

Molecular Formula: C₂₆H₄₁N₃O₅

Molecular Weight: 475.6

Purity: ≥98% by HPLC

Solubility: DMSO (10 mg/ml)

Storage Temp.: +4°C

Shipping Conditions: gel pack

Description: A cell-permeable, potent, and reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (ICâ‚…â‚€ = 3 µM). Prevents γ-secretase cleavage.

Handling: Protect from air and moisture