Pregnancy-Associated Plasma Protein-1
- 貨號 Cat. No.
- RCP9038
- 規格 Size
- 100 µg
- 品牌 Brand
- RANDOX-LIFESCIENCES
Description
| Description: | PAPP-A is a large zinc binding protein, which acts as a metalloprotease and has been shown to cleave insulin-like growth factor binding protein-4. PAPP-A can act as a regulator of IGF bioactivity in several biological systems, including the human ovary and cardiovascular systems. Recent studies have shown that levels are elevated in patients with unstable angina or acute myocardial infarction. PAPP-A is also produced in high concentrations during pregnancy and is released into the maternal circulation. Low levels of PAPP-A have been linked with a number of foetal chromosomal abnormalities, as well as pre-eclampsia and stillbirth. RANDOX recombinant PAPP-A comprises a 191 amino acid fragment (81-271) corresponding to the PAPP-A ‘Jelly-Roll’ domain fragment and is expressed in E. coli with an aminoterminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use. |
| Form: | Liquid |
| Purity: | >95% by SDS-PAGE |
| References: | Conover, C.A. et al., 2004 Development 131 (5) 1187-1194 |