PP-2A Antibody

h1 class=titlePP-2A Antibody/h1
div id=node-1339 class=node ntype-antibodiesMouse Polyclonal
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h4Catalog Number/h4
pstrong250830/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pThe serine/threonine protein phosphatase 2A catalytic subunit alpha isoform (PP2A alpha) modulates the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. PP2A alpha dephosphorylates the SV40nbsp; large T antigen and p53, dephosphorylates the SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. PP2A consists of a common heterodimeric cire enzyme composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (subunit A) that associates with a variety of regulatory subunits. The C subunit is the most active, followed by the AC form, which is more active than the ABC form, and activity of all three forms is strongly stimulated by manganese, and to a lesser extent by magnesium. This antibody reacts with the catalytic subunit (subunit C)./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; Replication protein C; RP-C; PPP2CA/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.org/uniprot/P67775P67775/abr /
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h4Clonality/h4
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h4Antigen/h4
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pKLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PP2A./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:100-1:500/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H | M | R/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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