PP-1 Antibody

h1 class=titlePP-1 Antibody/h1
div id=node-1641 class=node ntype-antibodiesMouse Polyclonal
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h4Catalog Number/h4
pstrong250829/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pThe protein phosphatase 1 (PP1) is essential for cell division and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. PP-1 is involved in the regulation of ionic conductances and long-term synaptic plasticity. PP-1 plays an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. PP-1 holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. The PP1 catalytic subunit can be PP1-alpha (PPP1CA), PP1-beta (PPP1CB) or PP1-gamma (PPP1CC), which is folded into its native form by inhibitor 2 and glycogen synthethase kinase 3, and then complexed to one or several targeting or regulatory subunits. This antibody recognizes PP1-alpha, PP1-beta and PP1-gamma./p
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h4Product Citations/h4
pnbsp;/p
h4Recommended Products/h4
pa href=http://abbiotec.com/antibodies/p53-antibody200143 - p53 Antibody/abr /
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h4Alternate Names/h4
pSerine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP-1A; PPP1CA; PPP1A; Serine/threonine-protein phosphatase PP1-beta catalytic subunit; PP-1B; PPP1CB; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; PP-1G; Protein phosphatase 1C catalytic subunit; PPP1CC/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P62136P62136/abr /
a class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P62140P62140/abr /
a class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P36873P36873/abr /
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h4Clonality/h4
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h4Antigen/h4
pnbsp;/p
pKLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PP-1./p
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h4Application Notes/h4
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pProduct Cat. No. 250829 recognizes PP1-alpha, PP1-beta and PP1-gamma./p
pE: 1:500-1:1,000/p
pWB: 1:100-1:500/p
pIHC: 1:200-1:500/p
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pstrongReacts with/strongnbsp; :H | M | R/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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