Plasminogen Activator Inhibitor 1
- 貨號 Cat. No.
- RCP9163
- 規格 Size
- 1 mg
- 品牌 Brand
- RANDOX-LIFESCIENCES
Description
| Description: | PAI-1 is a serine protease inhibitor, which can exist either in an active inhibitory conformation or in an inactive or latent conformation. PAI-1 is produced mainly by the endothelium but is also secreted by other tissue types including adipose tissue. PAI-1 is the principal inhibitor of tissue plasminogen activator and urokinase, therefore inhibiting fibrinolysis. Increased levels of PAI-1 have been linked with various conditions including cardiovascular disease, thrombosis, insulin resistance and obesity. RANDOX recombinant PAI-1 comprises a 379 amino acid fragment (24-402) corresponding to the mature PAI-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use. |
| Form: | Liquid |
| Purity: | >95% by SDS-PAGE |
| References: | Gils, A & Declerck, P.J. 2004 Curr. Med. Chem. 11 (17) : 2323- 2334 |