Plasma Renin Activity (PRA) RIA

pPlasma Renin Activity (PRA)nbsp;br /
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For Research Use Only/p
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div class=prod_spec_box
div class=prod_specFormat:/div
div class=prod_spec_infoRadioimmunoassay/div
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div class=prod_specSample Type:/div
div class=prod_spec_infoplasma, EDTA plasma/div
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div class=prod_specbSample Size:/b/div
div class=prod_spec_info1000 micro;l/div
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div class=prod_specbSize:/b/div
div class=prod_spec_info125 tests/div
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div class=prod_specbRange:/b/div
div class=prod_spec_info0.2 - 25 ng/ml/div
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div class=prod_specbSensitivity:/b/div
div class=prod_spec_info0.033 ng/ml/div
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div class=prod_specbIncubation Time:/b/div
div class=prod_spec_infoOvernight/div
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pbSummary:/b/p
Renin-angiotensin-aldosterone system is a hormonal ldquo;cascaderdquo; system, whose first compound is represented by angiotensinogen. Renin, a proteolitic enzyme, transforms angiotensinogen into angiotensin I a polipeptide which has not biological activity. Angiotensin I is the substrate on which converting enzyme acts, producing biologically active angiotensin II. The main biological actions of angiotensin II consist of vasoconstriction, regulation of synthesis and release of aldosterone which modulates electrolytes balance. Thus the system is involved in regulation of blood pressure with several mechanisms. It is possible to evaluate system activity by measurement of plasmatic renin activity, because either angiotensin I or renin assay have methodological problems (low values for the first one, presence of structurally similar enzymes for the second one). Renin is synthesized by iuxta-glomerular apparatus of kidney and it has a molecular weight about 40.000 Dalton. The measurement of its activity is a valid tool in order to determine prognosis and therapy for patients affected by blood hypertension./div
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