PKI-587
Chemical Compounds
- 貨號 Cat. No.
- M1772
- 規格 Size
- 10mg,50mg
- 品牌 Brand
- No Brand
Description
PKI-587 (PF-05212384) is a highly potent dual PI3K/mTOR kinase inhibitor.PKI-587 (PF-05212384)potently inhibited class I PI3Ks (IC (50) vs. PI3K-α = 0.4 nmol/L), PI3K-α mutants, and mTOR.PKI-587 (PF-05212384) inhibited growth of 50 diverse human tumor cell lines at IC (50) values of less than 1nm.PKI-587 (PF-05212384) also inhibit 236 human protein kinases (IC50s >10 μM.Only wild type and mutant (V600E) B-Rafs were inhibited by PKI-587 at IC50 values of 10μM.
