Antibodies
PIK-293
- 貨號 Cat. No.
- S2207
- 規格 Size
- 5~200mg
- 品牌 Brand
- Selleckchem
Description
PIK-293
PIK-293 is a PI3K inhibitor, mostly for PI3Kδ with IC50 of 0.24 μM, 500-, 100- and 50-fold less potent to PI3Kα/β/γ, respectively.
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Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
| Description | PIK-293 is a PI3K inhibitor, mostly for PI3Kδ with IC50 of 0.24 μM, 500-, 100- and 50-fold less potent to PI3Kα/β/γ, respectively. | |||||
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| Targets | p110α | p110β | p110δ | p110γ | ||
| IC50 | 100 μM | 25 μM | 0.24 μM | 10 μM [1] | ||
| In vitro | PIK-293 is a pyrazolopyrimidine analog of IC87114. PIK-293 is synthesized by replacing the adenine of IC87114 with the isosteric pyrazolopyrimidine. [1] | |||||
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| Features | ||||||
Protocol(Only for Reference)
References
Chemical Information
| Molecular Weight (MW) | 397.43 |
|---|---|
| Formula | C22H19N7O |
| CAS No. | 900185-01-5 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | N/A |
| Solubility (25°C) * | In vitro | DMSO | 80 mg/mL (201 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | 2-((4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one |
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Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
|---|---|---|---|---|
| Mass(mg) | 0.39743 | 3.9743 | 7.9486 | 11.9229 |
Customer Reviews (1)
 Click to enlarge | Rating | |
| Source | Dr. Zhang of Tianjin Medical University. PIK-293 purchased from Selleck | |
| Method | Western blot | |
| Cell Lines | A549 cells | |
| Concentrations | 0-1 μM | |
| Incubation Time | 3 h | |
| Results | PIK-293 treatment resulted in a reduction of AKT phosphorylation in A549 cells. |
