PicoProbe™ Fructose-1,6-Bisphosphatase Inhibitor Screening Kit (F)

Alternate Name :

Tag Line :

Simple assay for high-throughput screening of FBP1 inhibitors/activators

Storage Conditions: -20°C

Shelf life: 12 months

Summary :

• Detection method- Fluorescence (Ex/Em= 535/587 nm)
• Application-Screening/characterizing/studying DHFR inhibitors/activators

Detection Method: (Ex/Em= 535/587 nm)

Features & Benefits:

• Simple and reliable test to screen FBP1 inhibitors/activators
• High-throughput compatible
• Includes Inhibitor Control (AMP)

Description:

Fructose-1,6-bispohphatase (FBP1) is responsible for the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate in the rate determining step of gluconeogenesis. FBP1 is a tetramer that plays a role in regulating adiposity and appetite. FBP1 has emerged as an important therapeutic target to treat diabetes type 2 to regulate glucose levels during gluconeogenesis. In BioVision’s FBP1 Inhibitor Screening Kit, human FBP1 hydrolyzes fructose-1,6-bisphosphate to fructose-6-phosphate which oxidizes and reacts with a fluorogenic probe, that is detected at Ex/Em= 535/587 nm. The assay is fast, sensitive, high-throughput compatible and provides a quick and sensitive way for screening, studying and characterizing potential novel inhibitors of FBP1