PI-103

Alternate Name/Synonyms: 3-(4-(4-Morpholinyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenol

Appearance: Off-white solid

Formulation: N/A

CAS Number: 371935-74-9

Molecular Formula: C₁₉H₁₆N₄O₃

Molecular Weight: 348.36

Purity: ≥98% by HPLC

Solubility: DMSO (50 mM)

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: A cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. The ICâ‚…â‚€ values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively. Inhibits growth of human tumor xenografts in mice in vivo.

Handling: Protect from air and light