Antibodies
Phenoxybenzamine HCl
- 貨號 Cat. No.
- S2499
- 規格 Size
- 10mM/1mLã€50mg
- 品牌 Brand
- Selleckchem
Description
Phenoxybenzamine HCl
Catalog No.S2499
Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.
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Biological Activity
Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM. It is used as an anti-hypertensive due to its efficacy in reducing the vasoconstriction caused by adrenaline and noradrenaline. Phenoxybenzamine forms a permanent covalent bond with adrenergic receptors. It remains permanently bound to the receptor, preventing adrenaline and noradrenaline from binding. This causes vasodilatation in blood vessels, due to its antagonistic effect at the alpha-1 adrenoceptor found in the walls of blood vessels, resulting in a drop in blood pressure. [1][2]
Chemical Information
Download Phenoxybenzamine HCl SDF
| Molecular Weight (MW) | 340.3 |
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| Formula | C18H22ClNO.HCl |
| CAS No. | 63-92-3 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | N/A |
| Solubility (25°C) * | In vitro | DMSO | 68 mg/mL (199 mM) |
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| Water | 17 mg/mL (49 mM) | ||
| Ethanol | 68 mg/mL (199 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
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Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
|---|---|---|---|---|
| Mass(mg) | 0.3403 | 3.403 | 6.806 | 10.209 |
