Penitrem A
- 貨號 Cat. No.
- P-650
- 規格 Size
- 0.65 mg 5x0.65mg
Description
Penitrem A
A Mycotoxin Blocker of KCa1.1 (BK) Channels
| Product#: | P-650 |
| Sizes: |
| 0.65 mg |
| 5 x 0.65 mg |
| M.W.: | 634.2 |
| Purity: | >98% |
| Bioassay: |
| Inhibition of KCa1.1 channels expressed in Xenopus oocytes by mycotoxins. |
 |
| Time course of KCa1.1 channel current amplitude upon application of several mycotoxins including Penitrem A. Current amplitude was reduced by 100 nM Paxilline (a), Penitrem A (b) and Verruculogen (c). The horizontal bars represent period of toxin perfusion. |
| References: |
1. | Hollywood, M. A. et al. (2000) Am. J. Physiol. 279, C420 |
2. | Knaus, H.-G. et al. (1994) Biochemistry 33, 5819. |
3. | Norris, P.J. et al. (1980) J. Neurochem. 34, 33. |
Penitrem A is widely used to probe KCa1.1 channels in smooth muscle preparations, where it induces prolongation of the depolarization plateau potential.1 Penitrem A is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Verruculogen (#V-500) and Paxilline (#P-450).2 Penitrem A (400 mg mycelium/kg) increased the spontaneous release of endogenous glutamate, GABA (g-aminobutyric acid), and aspartate by 213%, 455%, and 277%, respectively, from rat cerebrocortical synaptosomes.3