PDGFRB Antibody

The PDGF Receptor Type B, a 190kD protein, appears to bind only the PDGF BB homodimer with high affinity, whereas the PDGF receptor type A (Alpha platelet-derived growth factor receptor precursor, CD140a antigen), a 170kD protein, binds all three isoforms of PDGF with high affinity. Both receptors are trans membranous, ligand activated protein tyrosine kinases which phosphorylate a number of important signal transduction proteins that are bound with differential affinities via SH2 domains.