PDGFRA Antibody

The PDGF receptor type A (Alpha platelet-derived growth factor receptor precursor, CD140a antigen) a 170kD protein, binds all three isoforms of PDGF with high affinity; whereas the PDGF Receptor Type B, a 190kD protein, appears to bind only the PDGF BB homodimer with high affinity . Both receptors are trans membranous, ligand activated protein tyrosine kinases which phosphorylate a number of important signal transduction proteins that are bound with differential affinities via SH2 domains.