PD 173074

Alternate Name/Synonyms: N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N’-(1,1-dimethylethyl)urea

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 219580-11-7

Molecular Formula: C₂₈H₄₁N₇O₃

Molecular Weight: 523.67

Purity: ≥98% by TLC

Solubility: DMSO (10 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: A potent and selective FGFR1 tyrosine kinase inhibitor (ICâ‚…â‚€ = 21.5 nM). Blocking of the FGFR signaling pathway by PD 173074 leads to self-renewal of stem cells via ERK1/2 activation. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 decreases dramatically their clonogenicity and differentiation potential.

Handling: Protect from air and light